Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349

[Image: see text] Aberrant activation of the PI3K-Akt-mTOR signaling pathway has been observed in human tumors and tumor cell lines, indicating that these protein kinases may be attractive therapeutic targets for treating cancer. Optimization of advanced lead 1 culminated in the discovery of clinica...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Pei, Zhonghua, Blackwood, Elizabeth, Liu, Lichuan, Malek, Shiva, Belvin, Marcia, Koehler, Michael F. T., Ortwine, Daniel F., Chen, Huifen, Cohen, Frederick, Kenny, Jane R., Bergeron, Philippe, Lau, Kevin, Ly, Cuong, Zhao, Xianrui, Estrada, Anthony A., Truong, Tom, Epler, Jennifer A., Nonomiya, Jim, Trinh, Lan, Sideris, Steve, Lesnick, John, Bao, Linda, Vijapurkar, Ulka, Mukadam, Sophie, Tay, Suzanne, Deshmukh, Gauri, Chen, Yung-Hsiang, Ding, Xiao, Friedman, Lori S., Lyssikatos, Joseph P.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2012
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027466/
https://ncbi.nlm.nih.gov/pubmed/24900569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml3003132
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars