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A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma
The PI3 kinase family of lipid kinases promotes cell growth and survival by generating the second messenger phosphatidylinositol-3,4,5-trisphosphate. To define targets critical for cancers driven by activation of PI3 kinase, we screened a panel of potent and structurally diverse drug-like molecules...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2006
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2925230/ https://ncbi.nlm.nih.gov/pubmed/16697955 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2006.03.029 |
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