EGFR Signals to mTOR Through PKC and Independently of Akt in Glioma

Amplification of the gene encoding the epidermal growth factor (EGF) receptor (EGFR) occurs commonly in glioblastoma, leading to activation of downstream kinases including phosphatidylinositol 3′-kinase (PI3K), Akt, and mammalian target of rapamycin (mTOR). Here, we show that phosphorylation of mTOR...

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Autori principali: Fan, Qi-Wen, Cheng, Christine, Knight, Zachary A., Haas-Kogan, Daphne, Stokoe, David, James, C. David, McCormick, Frank, Shokat, Kevan M., Weiss, William A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2793677/
https://ncbi.nlm.nih.gov/pubmed/19176518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000014
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