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EGFR Signals to mTOR Through PKC and Independently of Akt in Glioma
Amplification of the gene encoding the epidermal growth factor (EGF) receptor (EGFR) occurs commonly in glioblastoma, leading to activation of downstream kinases including phosphatidylinositol 3′-kinase (PI3K), Akt, and mammalian target of rapamycin (mTOR). Here, we show that phosphorylation of mTOR...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2793677/ https://ncbi.nlm.nih.gov/pubmed/19176518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000014 |
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