EGFR Signals to mTOR Through PKC and Independently of Akt in Glioma

Amplification of the gene encoding the epidermal growth factor (EGF) receptor (EGFR) occurs commonly in glioblastoma, leading to activation of downstream kinases including phosphatidylinositol 3′-kinase (PI3K), Akt, and mammalian target of rapamycin (mTOR). Here, we show that phosphorylation of mTOR...

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Bibliographische Detailangaben
Hauptverfasser: Fan, Qi-Wen, Cheng, Christine, Knight, Zachary A., Haas-Kogan, Daphne, Stokoe, David, James, C. David, McCormick, Frank, Shokat, Kevan M., Weiss, William A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2793677/
https://ncbi.nlm.nih.gov/pubmed/19176518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000014
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