EGFR Signals to mTOR Through PKC and Independently of Akt in Glioma

Amplification of the gene encoding the epidermal growth factor (EGF) receptor (EGFR) occurs commonly in glioblastoma, leading to activation of downstream kinases including phosphatidylinositol 3′-kinase (PI3K), Akt, and mammalian target of rapamycin (mTOR). Here, we show that phosphorylation of mTOR...

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Main Authors: Fan, Qi-Wen, Cheng, Christine, Knight, Zachary A., Haas-Kogan, Daphne, Stokoe, David, James, C. David, McCormick, Frank, Shokat, Kevan M., Weiss, William A.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2793677/
https://ncbi.nlm.nih.gov/pubmed/19176518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000014
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