PTEN promoter methylation and activation of the PI3K/Akt/mTOR pathway in pediatric gliomas and influence on clinical outcome

The signaling pathways that underlie the pathogenesis of pediatric gliomas are poorly understood. We characterized the PI3K/Akt/mTOR pathway in pediatric gliomas of all grades. Using immunohistochemistry, we assessed activation of the PI3K/Akt/mTOR pathway by evaluating the downstream signaling mole...

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Detalhes bibliográficos
Main Authors: Mueller, Sabine, Phillips, Joanna, Onar-Thomas, Arzu, Romero, Eloy, Zheng, Shichun, Wiencke, John K., McBride, Sean M., Cowdrey, Cynthia, Prados, Michael D., Weiss, William A., Berger, Mitchel S., Gupta, Nalin, Haas-Kogan, Daphne A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424210/
https://ncbi.nlm.nih.gov/pubmed/22753230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nos140
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