Reduced phosphocholine and hyperpolarized lactate provide magnetic resonance biomarkers of PI3K/Akt/mTOR inhibition in glioblastoma

The phosphatidylinositol-3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway is activated in more than88% of glioblastomas (GBM). New drugs targeting this pathway are currently in clinical trials. However, noninvasive assessment of treatment response remains challenging. By...

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Detalhes bibliográficos
Main Authors: Venkatesh, Humsa S., Chaumeil, Myriam M., Ward, Christopher S., Haas-Kogan, Daphne A., James, C. David, Ronen, Sabrina M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280799/
https://ncbi.nlm.nih.gov/pubmed/22156546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nor209
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