Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide

Due to its molecular heterogeneity and infiltrative nature, glioblastoma multiforme (GBM) is notoriously resistant to traditional and experimental therapeutics. To overcome these hurdles, targeted agents have been combined with conventional therapy. We evaluated the preclinical potential of a novel,...

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Detalhes bibliográficos
Main Authors: Prasad, Gautam, Sottero, Theo, Yang, Xiaodong, Mueller, Sabine, James, C. David, Weiss, William A., Polley, Mei-Yin, Ozawa, Tomoko, Berger, Mitchel S., Aftab, Dana T., Prados, Michael D., Haas-Kogan, Daphne A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064692/
https://ncbi.nlm.nih.gov/pubmed/21317208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noq193
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