Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide

Due to its molecular heterogeneity and infiltrative nature, glioblastoma multiforme (GBM) is notoriously resistant to traditional and experimental therapeutics. To overcome these hurdles, targeted agents have been combined with conventional therapy. We evaluated the preclinical potential of a novel,...

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Detalles Bibliográficos
Autores principales: Prasad, Gautam, Sottero, Theo, Yang, Xiaodong, Mueller, Sabine, James, C. David, Weiss, William A., Polley, Mei-Yin, Ozawa, Tomoko, Berger, Mitchel S., Aftab, Dana T., Prados, Michael D., Haas-Kogan, Daphne A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2011
Materias:
Basic and Translational Investigations
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064692/
https://ncbi.nlm.nih.gov/pubmed/21317208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noq193
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