Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide

Due to its molecular heterogeneity and infiltrative nature, glioblastoma multiforme (GBM) is notoriously resistant to traditional and experimental therapeutics. To overcome these hurdles, targeted agents have been combined with conventional therapy. We evaluated the preclinical potential of a novel,...

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Hlavní autoři: Prasad, Gautam, Sottero, Theo, Yang, Xiaodong, Mueller, Sabine, James, C. David, Weiss, William A., Polley, Mei-Yin, Ozawa, Tomoko, Berger, Mitchel S., Aftab, Dana T., Prados, Michael D., Haas-Kogan, Daphne A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2011
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064692/
https://ncbi.nlm.nih.gov/pubmed/21317208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noq193
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