Activation of PI3K/mTOR pathway occurs in most adult low-grade gliomas and predicts patient survival

Recent evidence suggests the Akt-mTOR pathway may play a role in development of low-grade gliomas (LGG). We sought to evaluate whether activation of this pathway correlates with survival in LGG by examining expression patterns of proteins within this pathway. Forty-five LGG tumor specimens from newl...

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Autores principales: McBride, Sean M., Perez, Daniel A., Polley, Mei-Yin, Vandenberg, Scott R., Smith, Justin S., Zheng, Shichun, Lamborn, Kathleen R., Wiencke, John K., Chang, Susan M., Prados, Michael D., Berger, Mitchel S., Stokoe, David, Haas-Kogan, Daphne A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer US 2009
Materias:
Laboratory Investigation - Human/Animal Tissue
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2814032/
https://ncbi.nlm.nih.gov/pubmed/19705067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-009-0004-4
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