Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma

Glioblastoma multiforme (GBM) can present as either de novo or secondary tumors arising from previously diagnosed low-grade gliomas. Although these tumor types are phenotypically indistinguishable, de novo and secondary GBMs are associated with distinct genetic characteristics. PTEN mutations, which...

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Autori principali: Wiencke, John K., Zheng, Shichun, Jelluma, Nanette, Tihan, Tarik, Vandenberg, Scott, Tamgüney, Tanja, Baumber, Rachel, Parsons, Ramon, Lamborn, Kathleen R., Berger, Mitchel S., Wrensch, Margaret R., Haas-Kogan, Daphne Adele, Stokoe, David
Natura: Artigo
Lingua:Inglês
Pubblicazione: Duke University Press 2007
Soggetti:
Basic and Translational Investigations
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1907411/
https://ncbi.nlm.nih.gov/pubmed/17504928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/15228517-2007-003
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