Akt and Autophagy Cooperate to Promote Survival of Drug-Resistant Glioma

Although the phosphatidylinositol 3-kinase to Akt to mammalian target of rapamycin (PI3K-Akt-mTOR) pathway promotes survival signaling, inhibitors of PI3K and mTOR induce minimal cell death in PTEN (phosphatase and tensin homolog deleted from chromosome 10 ) mutant glioma. Here, we show that the dua...

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Detalhes bibliográficos
Main Authors: Fan, Qi-Wen, Cheng, Christine, Hackett, Chris, Feldman, Morri, Houseman, Benjamin T., Nicolaides, Theodore, Haas-Kogan, Daphne, James, C. David, Oakes, Scott A., Debnath, Jayanta, Shokat, Kevan M., Weiss, William A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3001107/
https://ncbi.nlm.nih.gov/pubmed/21062993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2001017
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