Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL(+) leukemia cells

Some cases of pre–B cell acute lymphoblastic leukemia (pre–B-ALL) are caused by the Philadelphia (Ph) chromosome–encoded BCR-ABL oncogene, and these tend to have a poor prognosis. Inhibitors of the PI3K/AKT pathway reduce BCR-ABL–mediated transformation in vitro; however, the specific PI3K isoforms...

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Detalhes bibliográficos
Main Authors: Kharas, Michael G., Janes, Matthew R., Scarfone, Vanessa M., Lilly, Michael B., Knight, Zachary A., Shokat, Kevan M., Fruman, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2515380/
https://ncbi.nlm.nih.gov/pubmed/18704194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33337
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