A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability

Despite the approval of several multikinase inhibitors that target SRC and the overwhelming evidence of the role of SRC in the progression and resistance mechanisms of many solid malignancies, inhibition of its kinase activity has thus far failed to improve patient outcomes. Here we report the small...

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Bibliografske podrobnosti
izdano v:Cancer Res
Main Authors: Temps, Carolin, Lietha, Daniel, Webb, Emily R., Li, Xue-Feng, Dawson, John C., Muir, Morwenna, Macleod, Kenneth G., Valero, Teresa, Munro, Alison F., Contreras-Montoya, Rafael, Luque-Ortega, Juan R., Fraser, Craig, Beetham, Henry, Schoenherr, Christina, Lopalco, Maria, Arends, Mark J., Frame, Margaret C., Qian, Bin-Zhi, Brunton, Valerie G., Carragher, Neil O., Unciti-Broceta, Asier
Format: Artigo
Jezik:Inglês
Izdano: American Association for Cancer Research 2021
Teme:
Molecular Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611940/
https://ncbi.nlm.nih.gov/pubmed/34417202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-21-0613
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