A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability

Despite the approval of several multikinase inhibitors that target SRC and the overwhelming evidence of the role of SRC in the progression and resistance mechanisms of many solid malignancies, inhibition of its kinase activity has thus far failed to improve patient outcomes. Here we report the small...

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Vydáno v:Cancer Res
Hlavní autoři: Temps, Carolin, Lietha, Daniel, Webb, Emily R., Li, Xue-Feng, Dawson, John C., Muir, Morwenna, Macleod, Kenneth G., Valero, Teresa, Munro, Alison F., Contreras-Montoya, Rafael, Luque-Ortega, Juan R., Fraser, Craig, Beetham, Henry, Schoenherr, Christina, Lopalco, Maria, Arends, Mark J., Frame, Margaret C., Qian, Bin-Zhi, Brunton, Valerie G., Carragher, Neil O., Unciti-Broceta, Asier
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for Cancer Research 2021
Témata:
Molecular Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611940/
https://ncbi.nlm.nih.gov/pubmed/34417202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-21-0613
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