Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism That Prevents High-Fat Diet–Induced β-Cell Failure

Type 2 diabetes ultimately results from pancreatic β-cell failure. Abnormally elevated intracellular regeneration of glucocorticoids by the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in fat or liver may underlie pathophysiological aspects of the metabolic syndrome. Elevated 11β-HSD1 i...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Turban, Sophie, Liu, Xiaoxia, Ramage, Lynne, Webster, Scott P., Walker, Brian R., Dunbar, Donald R., Mullins, John J., Seckl, Jonathan R., Morton, Nicholas M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2012
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3282808/
https://ncbi.nlm.nih.gov/pubmed/22315313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1054
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados