Modulation of 11β-Hydroxysteroid Dehydrogenase Type 1 Activity by 1,5-Substituted 1H-Tetrazoles

Inhibitors of 11β-hydroxysteroid dehydrogenase (11β-HSD1) show promise as drugs to treat metabolic disease and CNS disorders such as cognitive impairment. A series of 1,5-substituted 1H-tetrazole 11β-HSD1 inhibitors has been discovered and chemically modified. Compounds are selective for 11β-HSD1 ov...

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Hauptverfasser: Webster, Scott P., Binnie, Margaret, McConnell, Kirsty M. M., Sooy, Karen, Ward, Peter, Greaney, Michael F., Vinter, Andy, Pallin, T. David, Dyke, Hazel J., Gill, Matthew I. A., Warner, Ines, Seckl, Jonathan R., Walker, Brian R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972730/
https://ncbi.nlm.nih.gov/pubmed/20452767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.04.055
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