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11β-Hydroxysteroid Dehydrogenases: Intracellular Gate-Keepers of Tissue Glucocorticoid Action

Glucocorticoid action on target tissues is determined by the density of “nuclear” receptors and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD) which catalyze interconversion of active cortisol and corticosterone with inert cortisone and 11-dehydrocorticost...

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Détails bibliographiques
Auteurs principaux: Chapman, Karen, Holmes, Megan, Seckl, Jonathan
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3962546/
https://ncbi.nlm.nih.gov/pubmed/23899562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physrev.00020.2012
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