Glucocorticoid Regulation of the Promoter of 11β-Hydroxysteroid Dehydrogenase Type 1 Is Indirect and Requires CCAAT/Enhancer-Binding Protein-β

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts inert 11keto-glucocorticoids to active 11β-hydroxy forms, thereby amplifying intracellular glucocorticoid action. Up-regulation of 11β-HSD1 in adipose tissue and liver is of pathogenic importance in metabolic syndrome. However, the mechanis...

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Опубликовано в: :Mol Endocrinol
Главные авторы: Sai, Shuji, Esteves, Cristina L., Kelly, Val, Michailidou, Zoi, Anderson, Karen, Coll, Anthony P., Nakagawa, Yuichi, Ohzeki, Takehiko, Seckl, Jonathan R., Chapman, Karen E.
Формат: Artigo
Язык:Inglês
Опубликовано: Endocrine Society 2008
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5419454/
https://ncbi.nlm.nih.gov/pubmed/18617597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2007-0489
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