Changing glucocorticoid action: 11β-Hydroxysteroid dehydrogenase type 1 in acute and chronic inflammation

Since the discovery of cortisone in the 1940s and its early success in treatment of rheumatoid arthritis, glucocorticoids have remained the mainstay of anti-inflammatory therapies. However, cortisone itself is intrinsically inert. To be effective, it requires conversion to cortisol, the active gluco...

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Main Authors: Chapman, Karen E., Coutinho, Agnes E., Zhang, Zhenguang, Kipari, Tiina, Savill, John S., Seckl, Jonathan R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Pergamon 2013
Ábhair:
Review
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3925798/
https://ncbi.nlm.nih.gov/pubmed/23435016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2013.02.002
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