Expression of 11beta-hydroxysteroid dehydrogenase 2 contributes to glucocorticoid resistance in lymphoblastic leukemia cells

Synthetic glucocorticoids (GC) form a crucial first-line treatment for childhood acute lymphoblastic leukemia (ALL). However prolonged GC therapy frequently leads to GC-resistance with an unclear molecular mechanism. 11β-hydroxysteroid dehydrogenase (11β-HSD) 2 inactivates GCs within cells. Here, we...

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Detalhes bibliográficos
Main Authors: Sai, Shuji, Nakagawa, Yuichi, Yamaguchi, Rie, Suzuki, Masako, Sakaguchi, Kimiyoshi, Okada, Shuichi, Seckl, Jonathan R., Ohzeki, Takehiko, Chapman, Karen E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977040/
https://ncbi.nlm.nih.gov/pubmed/21794917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2011.07.002
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