Modulation of 11β-Hydroxysteroid Dehydrogenase Type 1 Activity by 1,5-Substituted 1H-Tetrazoles

Inhibitors of 11β-hydroxysteroid dehydrogenase (11β-HSD1) show promise as drugs to treat metabolic disease and CNS disorders such as cognitive impairment. A series of 1,5-substituted 1H-tetrazole 11β-HSD1 inhibitors has been discovered and chemically modified. Compounds are selective for 11β-HSD1 ov...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Webster, Scott P., Binnie, Margaret, McConnell, Kirsty M. M., Sooy, Karen, Ward, Peter, Greaney, Michael F., Vinter, Andy, Pallin, T. David, Dyke, Hazel J., Gill, Matthew I. A., Warner, Ines, Seckl, Jonathan R., Walker, Brian R.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2010
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972730/
https://ncbi.nlm.nih.gov/pubmed/20452767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.04.055
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