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High-Resolution Crystal Structure of Endoplasmic Reticulum Aminopeptidase 1 with Bound Phosphinic Transition-State Analogue Inhibitor
[Image: see text] Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an intracellular enzyme that helps generate peptides presented by Major Histocompatibility Complex Class I (MHC class I) molecules and is an emerging target for immunotherapy applications. Despite almost two decades of research on E...
Enregistré dans:
| Publié dans: | ACS Med Chem Lett |
|---|---|
| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Chemical
Society
2019
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| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6511960/ https://ncbi.nlm.nih.gov/pubmed/31097987 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00002 |
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