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Screening Identifies Thimerosal as a Selective Inhibitor of Endoplasmic Reticulum Aminopeptidase 1

[Image: see text] We employed virtual screening followed by in vitro evaluation to discover novel inhibitors of ER aminopeptidase 1, an important enzyme for the human adaptive immune response that has emerged as an attractive target for cancer immunotherapy and the control of autoimmunity. Screening...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Stamogiannos, Athanasios, Papakyriakou, Athanasios, Mauvais, Francois-Xavier, van Endert, Peter, Stratikos, Efstratios
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2016
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948014/
https://ncbi.nlm.nih.gov/pubmed/27437077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00084
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