Screening Identifies Thimerosal as a Selective Inhibitor of Endoplasmic Reticulum Aminopeptidase 1

[Image: see text] We employed virtual screening followed by in vitro evaluation to discover novel inhibitors of ER aminopeptidase 1, an important enzyme for the human adaptive immune response that has emerged as an attractive target for cancer immunotherapy and the control of autoimmunity. Screening...

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Bibliografske podrobnosti
izdano v:ACS Med Chem Lett
Main Authors: Stamogiannos, Athanasios, Papakyriakou, Athanasios, Mauvais, Francois-Xavier, van Endert, Peter, Stratikos, Efstratios
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2016
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948014/
https://ncbi.nlm.nih.gov/pubmed/27437077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00084
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