Critical role of inter-domain interactions on the conformational change and catalytic mechanism of Endoplasmic Reticulum Aminopeptidase 1

Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) is an intracellular enzyme important for the generation of antigenic epitopes and class I MHC-restricted adaptive immune responses. ERAP1 processes a vast variety of different peptides but still shows length and sequence selectivity although the mechani...

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Détails bibliographiques
Publié dans:Biochemistry
Auteurs principaux: Stamogiannos, Athanasios, Maben, Zachary, Papakyriakou, Athanasios, Mpakali, Anastasia, Kokkala, Paraskevi, Georgiadis, Dimitris, Stern, Lawrence J., Stratikos, Efstratios
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6374128/
https://ncbi.nlm.nih.gov/pubmed/28218509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01170
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