Screening Identifies Thimerosal as a Selective Inhibitor of Endoplasmic Reticulum Aminopeptidase 1

[Image: see text] We employed virtual screening followed by in vitro evaluation to discover novel inhibitors of ER aminopeptidase 1, an important enzyme for the human adaptive immune response that has emerged as an attractive target for cancer immunotherapy and the control of autoimmunity. Screening...

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Bibliographic Details
Published in:ACS Med Chem Lett
Main Authors: Stamogiannos, Athanasios, Papakyriakou, Athanasios, Mauvais, Francois-Xavier, van Endert, Peter, Stratikos, Efstratios
Format: Artigo
Language:Inglês
Published: American Chemical Society 2016
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948014/
https://ncbi.nlm.nih.gov/pubmed/27437077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00084
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