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Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1
ERAP1 is an endoplasmic reticulum-resident zinc aminopeptidase that plays an important role in the immune system by trimming peptides for loading onto major histocompatibility complex (MHC-I) proteins. Here we report discovery of the first inhibitors selective for ERAP1 over its paralogs ERAP2 and I...
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| Publicat a: | J Med Chem |
|---|---|
| Autors principals: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8218592/ https://ncbi.nlm.nih.gov/pubmed/31841350 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00293 |
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