Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1

ERAP1 is an endoplasmic reticulum-resident zinc aminopeptidase that plays an important role in the immune system by trimming peptides for loading onto major histocompatibility complex (MHC-I) proteins. Here we report discovery of the first inhibitors selective for ERAP1 over its paralogs ERAP2 and I...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Maben, Zachary, Arya, Richa, Rane, Digamber, An, W. Frank, Metkar, Shailesh, Hickey, Marc, Bender, Samantha, Ali, Akbar, Nguyen, Tina T., Evnouchidou, Irini, Schilling, Roger, Stratikos, Efstratios, Golden, Jennifer, Stern, Lawrence J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8218592/
https://ncbi.nlm.nih.gov/pubmed/31841350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00293
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados