Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1

ERAP1 is an endoplasmic reticulum-resident zinc aminopeptidase that plays an important role in the immune system by trimming peptides for loading onto major histocompatibility complex (MHC-I) proteins. Here we report discovery of the first inhibitors selective for ERAP1 over its paralogs ERAP2 and I...

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Vydáno v:J Med Chem
Hlavní autoři: Maben, Zachary, Arya, Richa, Rane, Digamber, An, W. Frank, Metkar, Shailesh, Hickey, Marc, Bender, Samantha, Ali, Akbar, Nguyen, Tina T., Evnouchidou, Irini, Schilling, Roger, Stratikos, Efstratios, Golden, Jennifer, Stern, Lawrence J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8218592/
https://ncbi.nlm.nih.gov/pubmed/31841350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00293
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