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Crystal structures of ASK1-inhibtor complexes provide a platform for structure-based drug design
ASK1, a member of the MAPK Kinase Kinase family of proteins has been shown to play a key role in cancer, neurodegeneration and cardiovascular diseases and is emerging as a possible drug target. Here we describe a ‘replacement-soaking’ method that has enabled the high-throughput X-ray structure deter...
Tallennettuna:
| Päätekijät: | , , , , , , , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Blackwell Publishing Ltd
2013
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3832043/ https://ncbi.nlm.nih.gov/pubmed/23776076 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2298 |
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