Linking Murine and Human Plasmodium falciparum Challenge Models in a Translational Path for Antimalarial Drug Development

Effective progression of candidate antimalarials is dependent on optimal dosing in clinical studies, which is determined by a sound understanding of pharmacokinetics and pharmacodynamics (PK/PD). Recently, two important translational models for antimalarials have been developed: the NOD/SCID/IL2Rγ(−...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: McCarthy, James S., Marquart, Louise, Sekuloski, Silvana, Trenholme, Katharine, Elliott, Suzanne, Griffin, Paul, Rockett, Rebecca, O'Rourke, Peter, Sloots, Theo, Angulo-Barturen, Iñigo, Ferrer, Santiago, Jiménez-Díaz, María Belén, Martínez, María-Santos, van Huijsduijnen, Rob Hooft, Duparc, Stephan, Leroy, Didier, Wells, Timothy N. C., Baker, Mark, Möhrle, Jörg J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4879391/
https://ncbi.nlm.nih.gov/pubmed/27044554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02883-15
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