Design, synthesis and structure-activity relationship study of wollamide B; a new potential anti TB agent

Por Asfaw, Henok, Laqua, Katja, Walkowska, Anna Maria, Cunningham, Fraser, Martinez-Martinez, Maria Santos, Cuevas-Zurita, Juan Carlos, Ballell-Pages, Lluís, Imming, Peter
Publicado no PLoS One (2017)

Cyclopropyl Carboxamides: A New Oral Antimalarial Series Derived from the Tres Cantos Anti-Malarial Set (TCAMS)

Por Rueda, Lourdes, Castellote, Isabel, Castro-Pichel, Julia, Chaparro, Maria J., de la Rosa, Juan Carlos, Garcia-Perez, Adolfo, Gordo, Mariola, Jimenez-Diaz, Maria Belen, Kessler, Albane, Macdonald, Simon J.F., Martinez, Maria Santos, Sanz, Laura M., Gamo, Francisco Javier, Fernandez, Esther
Publicado em 2011

Cyclopropyl Carboxamides, a Chemically Novel Class of Antimalarial Agents Identified in a Phenotypic Screen

Por Sanz, Laura M., Jiménez-Díaz, M. Belen, Crespo, Benigno, De-Cozar, Cristina, Almela, M. Jesus, Angulo-Barturen, Iñigo, Castañeda, Pablo, Ibañez, Javier, Fernández, Esther Pilar, Ferrer, Santiago, Herreros, Esperanza, Lozano, Sonia, Martínez, María Santos, Rueda, Lourdes, Burrows, Jeremy N., García-Bustos, Jose F., Gamo, Francisco-Javier
Publicado em 2011

Linking Murine and Human Plasmodium falciparum Challenge Models in a Translational Path for Antimalarial Drug Development

Por McCarthy, James S., Marquart, Louise, Sekuloski, Silvana, Trenholme, Katharine, Elliott, Suzanne, Griffin, Paul, Rockett, Rebecca, O'Rourke, Peter, Sloots, Theo, Angulo-Barturen, Iñigo, Ferrer, Santiago, Jiménez-Díaz, María Belén, Martínez, María-Santos, van Huijsduijnen, Rob Hooft, Duparc, Stephan, Leroy, Didier, Wells, Timothy N. C., Baker, Mark, Möhrle, Jörg J.
Publicado no Antimicrob Agents Chemother (2016)

Histone Methyltransferase Inhibitors Are Orally Bioavailable, Fast-Acting Molecules with Activity against Different Species Causing Malaria in Humans

Por Malmquist, Nicholas A., Sundriyal, Sandeep, Caron, Joachim, Chen, Patty, Witkowski, Benoit, Menard, Didier, Suwanarusk, Rossarin, Renia, Laurent, Nosten, Francois, Jiménez-Díaz, María Belén, Angulo-Barturen, Iñigo, Martínez, María Santos, Ferrer, Santiago, Sanz, Laura M., Gamo, Francisco-Javier, Wittlin, Sergio, Duffy, Sandra, Avery, Vicky M., Ruecker, Andrea, Delves, Michael J., Sinden, Robert E., Fuchter, Matthew J., Scherf, Artur
Publicado no Antimicrob Agents Chemother (2015)

Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity

Por Kokkonda, Sreekanth, Deng, Xiaoyi, White, Karen L., Coteron, Jose M., Marco, Maria, de las Heras, Laura, White, John, El Mazouni, Farah, Tomchick, Diana R., Manjalanagara, Krishne, Rudra, Kakali Rani, Chen, Gong, Morizzi, Julia, Ryan, Eileen, Kaminsky, Werner, Leroy, Didier, Martínez-Martínez, María Santos, Jimenez-Diaz, Maria Belen, Bazaga, Santiago Ferrer, Angulo-Barturen, Iñigo, Waterson, David, Burrows, Jeremy N., Matthews, Dave, Charman, Susan A., Phillips, Margaret A., Rathod, Pradipsinh K.
Publicado no J Med Chem (2016)

Pyrazoleamide compounds are potent antimalarials that target Na(+) homeostasis in intraerythrocytic Plasmodium falciparum

Por Vaidya, Akhil B., Morrisey, Joanne M., Zhang, Zhongsheng, Das, Sudipta, Daly, Thomas M., Otto, Thomas D., Spillman, Natalie J., Wyvratt, Matthew, Siegl, Peter, Marfurt, Jutta, Wirjanata, Grennady, Sebayang, Boni F., Price, Ric N., Chatterjee, Arnab, Nagle, Advait, Stasiak, Marcin, Charman, Susan A., Angulo-Barturen, Iñigo, Ferrer, Santiago, Belén Jiménez-Díaz, María, Martínez, María Santos, Gamo, Francisco Javier, Avery, Vicky M., Ruecker, Andrea, Delves, Michael, Kirk, Kiaran, Berriman, Matthew, Kortagere, Sandhya, Burrows, Jeremy, Fan, Erkang, Bergman, Lawrence W.
Publicado no Nat Commun (2014)

Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials

Por Norcross, Neil R., Baragaña, Beatriz, Wilson, Caroline, Hallyburton, Irene, Osuna-Cabello, Maria, Norval, Suzanne, Riley, Jennifer, Stojanovski, Laste, Simeons, Frederick R. C., Porzelle, Achim, Grimaldi, Raffaella, Wittlin, Sergio, Duffy, Sandra, Avery, Vicky M., Meister, Stephan, Sanz, Laura, Jiménez-Díaz, Belén, Angulo-Barturen, Iñigo, Ferrer, Santiago, Martínez, María Santos, Gamo, Francisco Javier, Frearson, Julie A., Gray, David W., Fairlamb, Alan H., Winzeler, Elizabeth A., Waterson, David, Campbell, Simon F., Willis, Paul, Read, Kevin D., Gilbert, Ian H.
Publicado no J Med Chem (2016)

Identification of KasA as the cellular target of an anti-tubercular scaffold

Por Abrahams, Katherine A., Chung, Chun-wa, Ghidelli-Disse, Sonja, Rullas, Joaquín, Rebollo-López, María José, Gurcha, Sudagar S., Cox, Jonathan A. G., Mendoza, Alfonso, Jiménez-Navarro, Elena, Martínez-Martínez, María Santos, Neu, Margarete, Shillings, Anthony, Homes, Paul, Argyrou, Argyrides, Casanueva, Ruth, Loman, Nicholas J., Moynihan, Patrick J., Lelièvre, Joël, Selenski, Carolyn, Axtman, Matthew, Kremer, Laurent, Bantscheff, Marcus, Angulo-Barturen, Iñigo, Izquierdo, Mónica Cacho, Cammack, Nicholas C., Drewes, Gerard, Ballell, Lluis, Barros, David, Besra, Gurdyal S., Bates, Robert H.
Publicado no Nat Commun (2016)

Aminoindoles, a Novel Scaffold with Potent Activity against Plasmodium falciparum

Por Barker, Robert H., Urgaonkar, Sameer, Mazitschek, Ralph, Celatka, Cassandra, Skerlj, Renato, Cortese, Joseph F., Tyndall, Erin, Liu, Hanlan, Cromwell, Mandy, Sidhu, Amar Bir, Guerrero-Bravo, Jose E., Crespo-Llado, Keila N., Serrano, Adelfa E., Lin, Jing-wen, Janse, Chris J., Khan, Shahid M., Duraisingh, Manoj, Coleman, Bradley I., Angulo-Barturen, Inigo, Jiménez-Díaz, María Belén, Magán, Noemí, Gomez, Vanesa, Ferrer, Santiago, Martínez, María Santos, Wittlin, Sergio, Papastogiannidis, Petros, O'Shea, Thomas, Klinger, Jeffrey D., Bree, Mark, Lee, Edward, Levine, Mikaela, Wiegand, Roger C., Munoz, Benito, Wirth, Dyann F., Clardy, Jon, Bathurst, Ian, Sybertz, Edmund
Publicado em 2011

A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor (DSM421) with improved drug-like properties for treatment and prevention of malaria

Por Phillips, Margaret A., White, Karen L., Kokkonda, Sreekanth, Deng, Xiaoyi, White, John, El Mazouni, Farah, Marsh, Kennan, Tomchick, Diana R., Manjalanagara, Krishne, Rudra, Kakali Rani, Wirjanata, Grennady, Noviyanti, Rintis, Price, Ric N, Marfurt, Jutta, Shackleford, David M., Chiu, Francis C.K., Campbell, Michael, Jimenez-Diaz, Maria Belen, Bazaga, Santiago Ferrer, Angulo-Barturen, Iñigo, Martinez, Maria Santos, Lafuente-Monasterio, Maria, Kaminsky, Werner, Silue, Kigbafori, Zeeman, Anne-Marie, Kocken, Clemens, Leroy, Didier, Blasco, Benjamin, Rossignol, Emilie, Rueckle, Thomas, Matthews, Dave, Burrows, Jeremy N., Waterson, David, Palmer, Michael J., Rathod, Pradipsinh K., Charman, Susan A.
Publicado no ACS Infect Dis (2016)

Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose–Efficacy Modeling

Por Le Bihan, Amélie, de Kanter, Ruben, Angulo-Barturen, Iñigo, Binkert, Christoph, Boss, Christoph, Brun, Reto, Brunner, Ralf, Buchmann, Stephan, Burrows, Jeremy, Dechering, Koen J., Delves, Michael, Ewerling, Sonja, Ferrer, Santiago, Fischli, Christoph, Gamo–Benito, Francisco Javier, Gnädig, Nina F., Heidmann, Bibia, Jiménez-Díaz, María Belén, Leroy, Didier, Martínez, Maria Santos, Meyer, Solange, Moehrle, Joerg J., Ng, Caroline L., Noviyanti, Rintis, Ruecker, Andrea, Sanz, Laura María, Sauerwein, Robert W., Scheurer, Christian, Schleiferboeck, Sarah, Sinden, Robert, Snyder, Christopher, Straimer, Judith, Wirjanata, Grennady, Marfurt, Jutta, Price, Ric N., Weller, Thomas, Fischli, Walter, Fidock, David A., Clozel, Martine, Wittlin, Sergio
Publicado no PLoS Med (2016)

Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate

Por Hameed P., Shahul, Solapure, Suresh, Patil, Vikas, Henrich, Philipp P., Magistrado, Pamela A., Bharath, Sowmya, Murugan, Kannan, Viswanath, Pavithra, Puttur, Jayashree, Srivastava, Abhishek, Bellale, Eknath, Panduga, Vijender, Shanbag, Gajanan, Awasthy, Disha, Landge, Sudhir, Morayya, Sapna, Koushik, Krishna, Saralaya, Ramanatha, Raichurkar, Anandkumar, Rautela, Nikhil, Roy Choudhury, Nilanjana, Ambady, Anisha, Nandishaiah, Radha, Reddy, Jitendar, Prabhakar, K. R., Menasinakai, Sreenivasaiah, Rudrapatna, Suresh, Chatterji, Monalisa, Jiménez-Díaz, María Belén, Martínez, María Santos, Sanz, Laura María, Coburn-Flynn, Olivia, Fidock, David A., Lukens, Amanda K., Wirth, Dyann F., Bandodkar, Balachandra, Mukherjee, Kakoli, McLaughlin, Robert E., Waterson, David, Rosenbrier-Ribeiro, Lyn, Hickling, Kevin, Balasubramanian, V., Warner, Peter, Hosagrahara, Vinayak, Dudley, Adam, Iyer, Pravin S., Narayanan, Shridhar, Kavanagh, Stefan, Sambandamurthy, Vasan K.
Publicado no Nat Commun (2015)

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium

Por Jiménez-Díaz, María Belén, Ebert, Daniel, Salinas, Yandira, Pradhan, Anupam, Lehane, Adele M., Myrand-Lapierre, Marie-Eve, O’Loughlin, Kathleen G., Shackleford, David M., Justino de Almeida, Mariana, Carrillo, Angela K., Clark, Julie A., Dennis, Adelaide S. M., Diep, Jonathon, Deng, Xiaoyan, Duffy, Sandra, Endsley, Aaron N., Fedewa, Greg, Guiguemde, W. Armand, Gómez, María G., Holbrook, Gloria, Horst, Jeremy, Kim, Charles C., Liu, Jian, Lee, Marcus C. S., Matheny, Amy, Martínez, María Santos, Miller, Gregory, Rodríguez-Alejandre, Ane, Sanz, Laura, Sigal, Martina, Spillman, Natalie J., Stein, Philip D., Wang, Zheng, Zhu, Fangyi, Waterson, David, Knapp, Spencer, Shelat, Anang, Avery, Vicky M., Fidock, David A., Gamo, Francisco-Javier, Charman, Susan A., Mirsalis, Jon C., Ma, Hongshen, Ferrer, Santiago, Kirk, Kiaran, Angulo-Barturen, Iñigo, Kyle, Dennis E., DeRisi, Joseph L., Floyd, David M., Guy, R. Kiplin
Publicado no Proc Natl Acad Sci U S A (2014)

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

Por Phillips, Margaret A., Lotharius, Julie, Marsh, Kennan, White, John, Dayan, Anthony, White, Karen L., Njoroge, Jacqueline W., El Mazouni, Farah, Lao, Yanbin, Kokkonda, Sreekanth, Tomchick, Diana R., Deng, Xiaoyi, Laird, Trevor, Bhatia, Sangeeta N., March, Sandra, Ng, Caroline L., Fidock, David A., Wittlin, Sergio, Lafuente-Monasterio, Maria, Benito, Francisco Javier Gamo, Alonso, Laura Maria Sanz, Martinez, Maria Santos, Jimenez-Diaz, Maria Belen, Bazaga, Santiago Ferrer, Angulo-Barturen, Iñigo, Haselden, John N., Louttit, James, Cui, Yi, Sridhar, Arun, Zeeman, Anna-Marie, Kocken, Clemens, Sauerwein, Robert, Dechering, Koen, Avery, Vicky M., Duffy, Sandra, Delves, Michael, Sinden, Robert, Ruecker, Andrea, Wickham, Kristina S., Rochford, Rosemary, Gahagen, Janet, Iyer, Lalitha, Riccio, Ed, Mirsalis, Jon, Bathhurst, Ian, Rueckle, Thomas, Ding, Xavier, Campo, Brice, Leroy, Didier, Rogers, M. John, Rathod, Pradipsinh K., Burrows, Jeremy N., Charman, Susan A.
Publicado no Sci Transl Med (2015)

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

Por O'Neill, Paul M., Amewu, Richard K., Charman, Susan A., Sabbani, Sunil, Gnädig, Nina F., Straimer, Judith, Fidock, David A., Shore, Emma R., Roberts, Natalie L., Wong, Michael H.-L., Hong, W. David, Pidathala, Chandrakala, Riley, Chris, Murphy, Ben, Aljayyoussi, Ghaith, Gamo, Francisco Javier, Sanz, Laura, Rodrigues, Janneth, Cortes, Carolina Gonzalez, Herreros, Esperanza, Angulo-Barturén, Iñigo, Jiménez-Díaz, María Belén, Bazaga, Santiago Ferrer, Martínez-Martínez, María Santos, Campo, Brice, Sharma, Raman, Ryan, Eileen, Shackleford, David M., Campbell, Simon, Smith, Dennis A., Wirjanata, Grennady, Noviyanti, Rintis, Price, Ric N., Marfurt, Jutta, Palmer, Michael J., Copple, Ian M., Mercer, Amy E., Ruecker, Andrea, Delves, Michael J., Sinden, Robert E., Siegl, Peter, Davies, Jill, Rochford, Rosemary, Kocken, Clemens H. M., Zeeman, Anne-Marie, Nixon, Gemma L., Biagini, Giancarlo A., Ward, Stephen A.
Publicado no Nat Commun (2017)

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase

Por Paquet, Tanya, Le Manach, Claire, Cabrera, Diego González, Younis, Yassir, Henrich, Philipp P., Abraham, Tara S., Lee, Marcus C. S., Basak, Rajshekhar, Ghidelli-Disse, Sonja, Lafuente-Monasterio, María José, Bantscheff, Marcus, Ruecker, Andrea, Blagborough, Andrew M., Zakutansky, Sara E., Zeeman, Anne-Marie, White, Karen L., Shackleford, David M., Mannila, Janne, Morizzi, Julia, Scheurer, Christian, Angulo-Barturen, Iñigo, Martínez, María Santos, Ferrer, Santiago, Sanz, Laura María, Gamo, Francisco Javier, Reader, Janette, Botha, Mariette, Dechering, Koen J., Sauerwein, Robert W., Tungtaeng, Anchalee, Vanachayangkul, Pattaraporn, Lim, Chek Shik, Burrows, Jeremy, Witty, Michael J., Marsh, Kennan C., Bodenreider, Christophe, Rochford, Rosemary, Solapure, Suresh M., Jiménez-Díaz, María Belén, Wittlin, Sergio, Charman, Susan A., Donini, Cristina, Campo, Brice, Birkholtz, Lyn-Marie, Hanson, Kirsten K., Drewes, Gerard, Kocken, Clemens H. M., Delves, Michael J., Leroy, Didier, Fidock, David A., Waterson, David, Street, Leslie J., Chibale, Kelly
Publicado no Sci Transl Med (2017)

A novel multiple-stage antimalarial agent that inhibits protein synthesis

Por Baragaña, Beatriz, Hallyburton, Irene, Lee, Marcus C. S., Norcross, Neil R., Grimaldi, Raffaella, Otto, Thomas D., Proto, William R., Blagborough, Andrew M., Meister, Stephan, Wirjanata, Grennady, Ruecker, Andrea, Upton, Leanna M., Abraham, Tara S., Almeida, Mariana J., Pradhan, Anupam, Porzelle, Achim, Martínez, María Santos, Bolscher, Judith M., Woodland, Andrew, Norval, Suzanne, Zuccotto, Fabio, Thomas, John, Simeons, Frederick, Stojanovski, Laste, Osuna-Cabello, Maria, Brock, Paddy M., Churcher, Tom S., Sala, Katarzyna A., Zakutansky, Sara E., Jiménez-Díaz, María Belén, Sanz, Laura Maria, Riley, Jennifer, Basak, Rajshekhar, Campbell, Michael, Avery, Vicky M., Sauerwein, Robert W, Dechering, Koen J., Noviyanti, Rintis, Campo, Brice, Frearson, Julie A., Angulo-Barturen, Iñigo, Ferrer-Bazaga, Santiago, Gamo, Francisco Javier, Wyatt, Paul G., Leroy, Didier, Siegl, Peter, Delves, Michael J., Kyle, Dennis E., Wittlin, Sergio, Marfurt, Jutta, Price, Ric N., Sinden, Robert E., Winzeler, Elizabeth, Charman, Susan A., Bebrevska, Lidiya, Gray, David W., Campbell, Simon, Fairlamb, Alan H., Willis, Paul, Rayner, Julian C., Fidock, David A., Read, Kevin D., Gilbert, Ian H.
Publicado no Nature (2015)