Aminoindoles, a Novel Scaffold with Potent Activity against Plasmodium falciparum

This study characterizes aminoindole molecules that are analogs of Genz-644442. Genz-644442 was identified as a hit in a screen of ∼70,000 compounds in the Broad Institute's small-molecule library and the ICCB-L compound collection at Harvard Medical School. Genz-644442 is a potent inhibitor of...

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Detalhes bibliográficos
Main Authors: Barker, Robert H., Urgaonkar, Sameer, Mazitschek, Ralph, Celatka, Cassandra, Skerlj, Renato, Cortese, Joseph F., Tyndall, Erin, Liu, Hanlan, Cromwell, Mandy, Sidhu, Amar Bir, Guerrero-Bravo, Jose E., Crespo-Llado, Keila N., Serrano, Adelfa E., Lin, Jing-wen, Janse, Chris J., Khan, Shahid M., Duraisingh, Manoj, Coleman, Bradley I., Angulo-Barturen, Inigo, Jiménez-Díaz, María Belén, Magán, Noemí, Gomez, Vanesa, Ferrer, Santiago, Martínez, María Santos, Wittlin, Sergio, Papastogiannidis, Petros, O'Shea, Thomas, Klinger, Jeffrey D., Bree, Mark, Lee, Edward, Levine, Mikaela, Wiegand, Roger C., Munoz, Benito, Wirth, Dyann F., Clardy, Jon, Bathurst, Ian, Sybertz, Edmund
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101419/
https://ncbi.nlm.nih.gov/pubmed/21422215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01714-10
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