Optimization of Potent Inhibitors of P. falciparum Dihydroorotate Dehydrogenase for the Treatment of Malaria

[Image: see text] Inhibition of dihydroorotate dehydrogenase (DHODH) for P. falciparum potentially represents a new treatment option for malaria, since DHODH catalyzes the rate-limiting step in the pyrimidine biosynthetic pathway and P. falciparum is unable to salvage pyrimidines and must rely on de...

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Detalhes bibliográficos
Main Authors: Skerlj, Renato T., Bastos, Cecilia M., Booker, Michael L., Kramer, Martin L., Barker, Robert H., Celatka, Cassandra A., O’Shea, Thomas J., Munoz, Benito, Sidhu, Amar Bir, Cortese, Joseph F., Wittlin, Sergio, Papastogiannidis, Petros, Angulo-Barturen, Inigo, Jimenez-Diaz, Maria Belen, Sybertz, Edmund
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018051/
https://ncbi.nlm.nih.gov/pubmed/24900364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200143c
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