Identification and Characterization of Small Molecule Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase

Plasmodium falciparum causes the most deadly form of malaria and accounts for over one million deaths annually. The malaria parasite is unable to salvage pyrimidines and relies on de novo biosynthesis for survival. Dihydroorotate dehydrogenase (DHOD), a mitochondrially localized flavoenzyme, catalyz...

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Detalhes bibliográficos
Main Authors: Patel, Vishal, Booker, Michael, Kramer, Martin, Ross, Leila, Celatka, Cassandra A., Kennedy, Leah M., Dvorin, Jeffrey D., Duraisingh, Manoj T., Sliz, Piotr, Wirth, Dyann F., Clardy, Jon
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Enzyme Catalysis and Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596402/
https://ncbi.nlm.nih.gov/pubmed/18842591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804990200
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