Optimization of Potent Inhibitors of P. falciparum Dihydroorotate Dehydrogenase for the Treatment of Malaria

[Image: see text] Inhibition of dihydroorotate dehydrogenase (DHODH) for P. falciparum potentially represents a new treatment option for malaria, since DHODH catalyzes the rate-limiting step in the pyrimidine biosynthetic pathway and P. falciparum is unable to salvage pyrimidines and must rely on de...

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Hlavní autoři: Skerlj, Renato T., Bastos, Cecilia M., Booker, Michael L., Kramer, Martin L., Barker, Robert H., Celatka, Cassandra A., O’Shea, Thomas J., Munoz, Benito, Sidhu, Amar Bir, Cortese, Joseph F., Wittlin, Sergio, Papastogiannidis, Petros, Angulo-Barturen, Inigo, Jimenez-Diaz, Maria Belen, Sybertz, Edmund
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2011
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018051/
https://ncbi.nlm.nih.gov/pubmed/24900364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200143c
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