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Optimization of Potent Inhibitors of P. falciparum Dihydroorotate Dehydrogenase for the Treatment of Malaria
[Image: see text] Inhibition of dihydroorotate dehydrogenase (DHODH) for P. falciparum potentially represents a new treatment option for malaria, since DHODH catalyzes the rate-limiting step in the pyrimidine biosynthetic pathway and P. falciparum is unable to salvage pyrimidines and must rely on de...
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| Hlavní autoři: | , , , , , , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Chemical Society
2011
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4018051/ https://ncbi.nlm.nih.gov/pubmed/24900364 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200143c |
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