Recent clinical and molecular insights into emerging artemisinin resistance in Plasmodium falciparum

par O’Brien, Connor, Henrich, Philipp P., Passi, Neha, Fidock, David A.
Publié 2011

Branching Network of Proteinaceous Filaments within the Parasitophorous Vacuole of Encephalitozoon cuniculi and Encephalitozoon hellem

par Ghosh, Kaya, Nieves, Eddie, Keeling, Patrick, Pombert, Jean-Francois, Henrich, Philipp P., Cali, Ann, Weiss, Louis M.
Publié 2011

Evidence for Pyronaridine as a Highly Effective Partner Drug for Treatment of Artemisinin-Resistant Malaria in a Rodent Model

par Henrich, Philipp P., O'Brien, Connor, Sáenz, Fabián E., Cremers, Serge, Kyle, Dennis E., Fidock, David A.
Publié 2014

Trafficking of STEVOR to the Maurer's clefts in Plasmodium falciparum-infected erythrocytes

par Przyborski, Jude M, Miller, Susanne K, Pfahler, Judith M, Henrich, Philipp P, Rohrbach, Petra, Crabb, Brendan S, Lanzer, Michael
Publié 2005

Global Spread of Mutant PfCRT and Its Pleiotropic Impact on Plasmodium falciparum Multidrug Resistance and Fitness

par Dhingra, Satish K., Gabryszewski, Stanislaw J., Small-Saunders, Jennifer L., Yeo, Tomas, Henrich, Philipp P., Mok, Sachel, Fidock, David A.
Publié dans mBio (2019)

Substrate and Inhibitor Specificity of the Plasmodium berghei Equilibrative Nucleoside Transporter Type 1

par Arora, Avish, Deniskin, Roman, Sosa, Yvett, Nishtala, Sita Nirupama, Henrich, Philipp P., Kumar, T.R. Santha, Fidock, David A., Akabas, Myles H.
Publié dans Mol Pharmacol (2016)

In vitro and in vivo activity of frenolicin B against Plasmodium falciparum and P berghei

par Fitzgerald, Jay T, Henrich, Philipp P, O’Brien, Connor, Krause, Michael, Ekland, Eric H, Mattheis, Corinna, Sá, Juliana M, Fidock, David, Khosla, Chaitan
Publié dans J Antibiot (Tokyo) (2011)

Identification of a Role for the PfEMP1 Semi-Conserved Head Structure in Protein Trafficking to the Surface of Plasmodium falciparum Infected Red Blood Cells

par Melcher, Martin, Muhle, Rebecca A., Henrich, Philipp P., Kraemer, Susan M., Avril, Marion, Vigan-Womas, Ines, Mercereau-Puijalon, Odile, Smith, Joseph D., Fidock, David A.
Publié 2010

Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies

par Veiga, M. Isabel, Dhingra, Satish K., Henrich, Philipp P., Straimer, Judith, Gnädig, Nina, Uhlemann, Anne-Catrin, Martin, Rowena E., Lehane, Adele M., Fidock, David A.
Publié dans Nat Commun (2016)

In Vivo and In Vitro Antimalarial Properties of Azithromycin-Chloroquine Combinations That Include the Resistance Reversal Agent Amlodipine

par Pereira, Marcus R., Henrich, Philipp P., Sidhu, Amar bir Singh, Johnson, David, Hardink, Joel, Van Deusen, Jeffrey, Lin, Jian, Gore, Katrina, O'Brien, Connor, Wele, Mamadou, Djimde, Abdoulaye, Chandra, Richa, Fidock, David A.
Publié 2011

Quinine Dimers Are Potent Inhibitors of the Plasmodium falciparum Chloroquine Resistance Transporter and Are Active against Quinoline-Resistant P. falciparum

par Hrycyna, Christine A., Summers, Robert L., Lehane, Adele M., Pires, Marcos M., Namanja, Hilda, Bohn, Kelsey, Kuriakose, Jerrin, Ferdig, Michael, Henrich, Philipp P., Fidock, David A., Kirk, Kiaran, Chmielewski, Jean, Martin, Rowena E.
Publié 2014

A Key Role for Lipoic Acid Synthesis During Plasmodium Liver stage Development

par Falkard, Brie, Santha Kumar, T. R., Hecht, Leonie-Sophie, Matthews, Krista A., Henrich, Philipp P., Gulati, Sonia, Lewis, Rebecca E., Manary, Micah J., Winzeler, Elizabeth A., Sinnis, Photini, Prigge, Sean T., Heussler, Volker, Deschermeier, Christina, Fidock, David
Publié 2013

A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine

par Dhingra, Satish K., Redhi, Devasha, Combrinck, Jill M., Yeo, Tomas, Okombo, John, Henrich, Philipp P., Cowell, Annie N., Gupta, Purva, Stegman, Matthew L., Hoke, Jonathan M., Cooper, Roland A., Winzeler, Elizabeth, Mok, Sachel, Egan, Timothy J., Fidock, David A.
Publié dans mBio (2017)

Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiol...

par Gabryszewski, Stanislaw J., Dhingra, Satish K., Combrinck, Jill M., Lewis, Ian A., Callaghan, Paul S., Hassett, Matthew R., Siriwardana, Amila, Henrich, Philipp P., Lee, Andrew H., Gnädig, Nina F., Musset, Lise, Llinás, Manuel, Egan, Timothy J., Roepe, Paul D., Fidock, David A.
Publié dans PLoS Pathog (2016)

Association of a Novel Mutation in the Plasmodium falciparum Chloroquine Resistance Transporter With Decreased Piperaquine Sensitivity

par Agrawal, Sonia, Moser, Kara A, Morton, Lindsay, Cummings, Michael P, Parihar, Ankita, Dwivedi, Ankit, Shetty, Amol C, Drabek, Elliott F, Jacob, Christopher G, Henrich, Philipp P, Parobek, Christian M, Jongsakul, Krisada, Huy, Rekol, Spring, Michele D, Lanteri, Charlotte A, Chaorattanakawee, Suwanna, Lon, Chanthap, Fukuda, Mark M, Saunders, David L, Fidock, David A, Lin, Jessica T, Juliano, Jonathan J, Plowe, Christopher V, Silva, Joana C, Takala-Harrison, Shannon
Publié dans J Infect Dis (2017)

Hexahydroquinolines are Antimalarial Candidates with Potent Blood Stage and Transmission-Blocking Activity

par Vanaerschot, Manu, Lucantoni, Leonardo, Li, Tao, Combrinck, Jill M., Ruecker, Andrea, Kumar, T.R. Santha, Rubiano, Kelly, Ferreira, Pedro E., Siciliano, Giulia, Gulati, Sonia, Henrich, Philipp P., Ng, Caroline L., Murithi, James M., Corey, Victoria C., Duffy, Sandra, Lieberman, Ori J., Veiga, M. Isabel, Sinden, Robert E., Alano, Pietro, Delves, Michael J., Sim, Kim Lee, Winzeler, Elizabeth A., Egan, Timothy J., Hoffman, Stephen L., Avery, Vicky M., Fidock, David A.
Publié dans Nat Microbiol (2017)

Targeting Plasmodium phosphatidylinositol 4-kinase to eliminate malaria

par McNamara, Case W, Lee, Marcus CS, Lim, Chek Shik, Lim, Siau Hoi, Roland, Jason, Simon, Oliver, Yeung, Bryan KS, Chatterjee, Arnab K, McCormack, Susan L, Manary, Micah J, Zeeman, Anne-Marie, Dechering, Koen J, Kumar, TR Santha, Henrich, Philipp P, Gagaring, Kerstin, Ibanez, Maureen, Kato, Nobutaka, Kuhen, Kelli L, Fischli, Christoph, Nagle, Advait, Rottmann, Matthias, Plouffe, David M, Bursulaya, Badry, Meister, Stephan, Rameh, Lucia, Trappe, Joerg, Haasen, Dorothea, Timmerman, Martijn, Sauerwein, Robert W, Suwanarusk, Rossarin, Russell, Bruce, Renia, Laurent, Nosten, Francois, Tully, David C, Kocken, Clemens HM, Glynne, Richard J, Bodenreider, Christophe, Fidock, David A, Diagana, Thierry T, Winzeler, Elizabeth A
Publié 2013

Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate

par Hameed P., Shahul, Solapure, Suresh, Patil, Vikas, Henrich, Philipp P., Magistrado, Pamela A., Bharath, Sowmya, Murugan, Kannan, Viswanath, Pavithra, Puttur, Jayashree, Srivastava, Abhishek, Bellale, Eknath, Panduga, Vijender, Shanbag, Gajanan, Awasthy, Disha, Landge, Sudhir, Morayya, Sapna, Koushik, Krishna, Saralaya, Ramanatha, Raichurkar, Anandkumar, Rautela, Nikhil, Roy Choudhury, Nilanjana, Ambady, Anisha, Nandishaiah, Radha, Reddy, Jitendar, Prabhakar, K. R., Menasinakai, Sreenivasaiah, Rudrapatna, Suresh, Chatterji, Monalisa, Jiménez-Díaz, María Belén, Martínez, María Santos, Sanz, Laura María, Coburn-Flynn, Olivia, Fidock, David A., Lukens, Amanda K., Wirth, Dyann F., Bandodkar, Balachandra, Mukherjee, Kakoli, McLaughlin, Robert E., Waterson, David, Rosenbrier-Ribeiro, Lyn, Hickling, Kevin, Balasubramanian, V., Warner, Peter, Hosagrahara, Vinayak, Dudley, Adam, Iyer, Pravin S., Narayanan, Shridhar, Kavanagh, Stefan, Sambandamurthy, Vasan K.
Publié dans Nat Commun (2015)

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase

par Paquet, Tanya, Le Manach, Claire, Cabrera, Diego González, Younis, Yassir, Henrich, Philipp P., Abraham, Tara S., Lee, Marcus C. S., Basak, Rajshekhar, Ghidelli-Disse, Sonja, Lafuente-Monasterio, María José, Bantscheff, Marcus, Ruecker, Andrea, Blagborough, Andrew M., Zakutansky, Sara E., Zeeman, Anne-Marie, White, Karen L., Shackleford, David M., Mannila, Janne, Morizzi, Julia, Scheurer, Christian, Angulo-Barturen, Iñigo, Martínez, María Santos, Ferrer, Santiago, Sanz, Laura María, Gamo, Francisco Javier, Reader, Janette, Botha, Mariette, Dechering, Koen J., Sauerwein, Robert W., Tungtaeng, Anchalee, Vanachayangkul, Pattaraporn, Lim, Chek Shik, Burrows, Jeremy, Witty, Michael J., Marsh, Kennan C., Bodenreider, Christophe, Rochford, Rosemary, Solapure, Suresh M., Jiménez-Díaz, María Belén, Wittlin, Sergio, Charman, Susan A., Donini, Cristina, Campo, Brice, Birkholtz, Lyn-Marie, Hanson, Kirsten K., Drewes, Gerard, Kocken, Clemens H. M., Delves, Michael J., Leroy, Didier, Fidock, David A., Waterson, David, Street, Leslie J., Chibale, Kelly
Publié dans Sci Transl Med (2017)