Quinine Dimers Are Potent Inhibitors of the Plasmodium falciparum Chloroquine Resistance Transporter and Are Active against Quinoline-Resistant P. falciparum

[Image: see text] Chloroquine (CQ) resistance in the human malaria parasite Plasmodium falciparum is primarily conferred by mutations in the “chloroquine resistance transporter” (PfCRT). The resistance-conferring form of PfCRT (PfCRT(CQR)) mediates CQ resistance by effluxing the drug from the parasi...

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Bibliografski detalji
Glavni autori: Hrycyna, Christine A., Summers, Robert L., Lehane, Adele M., Pires, Marcos M., Namanja, Hilda, Bohn, Kelsey, Kuriakose, Jerrin, Ferdig, Michael, Henrich, Philipp P., Fidock, David A., Kirk, Kiaran, Chmielewski, Jean, Martin, Rowena E.
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068143/
https://ncbi.nlm.nih.gov/pubmed/24369685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb4008953
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