Chlorpheniramine Analogues Reverse Chloroquine Resistance in Plasmodium falciparum by Inhibiting PfCRT

[Image: see text] The emergence and spread of malaria parasites that are resistant to chloroquine (CQ) has been a disaster for world health. The antihistamine chlorpheniramine (CP) partially resensitizes CQ-resistant (CQR) parasites to CQ but possesses little intrinsic antiplasmodial activity. Mutat...

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Bibliographic Details
Main Authors: Deane, Karen J., Summers, Robert L., Lehane, Adele M., Martin, Rowena E., Barrow, Russell A.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027738/
https://ncbi.nlm.nih.gov/pubmed/24900883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5000228
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