Differential Drug Efflux or Accumulation Does Not Explain Variation in the Chloroquine Response of Plasmodium falciparum Strains Expressing the Same Isoform of Mutant PfCRT

Mutant forms of the Plasmodium falciparum chloroquine resistance transporter (PfCRT) mediate chloroquine resistance by effluxing the drug from the parasite's digestive vacuole, the acidic organelle in which chloroquine exerts its parasiticidal effect. However, different parasites bearing the sa...

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Autors principals: Lehane, Adele M., van Schalkwyk, Donelly A., Valderramos, Stephanie G., Fidock, David A., Kirk, Kiaran
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2011
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088201/
https://ncbi.nlm.nih.gov/pubmed/21343459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01167-10
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