Back to the Future: Lessons Learned in Modern Target-based and Whole-Cell Lead Optimization of Antimalarials

Por Chatterjee, Arnab K, Yeung, Bryan KS
Publicado em 2012

Antimalarial Drug Discovery: Approaches and Progress towards New Medicines

Por Flannery, Erika L., Chatterjee, Arnab K., Winzeler, Elizabeth A.
Publicado em 2013

Small molecule selectively suppresses MYC transcription in cancer cells

Por Bouvard, Claire, Lim, Sang Min, Ludka, John, Yazdani, Nahid, Woods, Ashley K., Chatterjee, Arnab K., Schultz, Peter G., Zhu, Shoutian
Publicado no Proc Natl Acad Sci U S A (2017)

A high-throughput phenotypic screen identifies clofazimine as a potential treatment for cryptosporidiosis

Por Love, Melissa S., Beasley, Federico C., Jumani, Rajiv S., Wright, Timothy M., Chatterjee, Arnab K., Huston, Christopher D., Schultz, Peter G., McNamara, Case W.
Publicado no PLoS Negl Trop Dis (2017)

Dissociated sterol-based liver X receptor agonists as therapeutics for chronic inflammatory diseases

Por Yu, Shan, Li, Sijia, Henke, Adam, Muse, Evan D., Cheng, Bo, Welzel, Gustav, Chatterjee, Arnab K., Wang, Danling, Roland, Jason, Glass, Christopher K., Tremblay, Matthew
Publicado no FASEB J (2016)

Small molecule inhibitors of trans-translation have broad-spectrum antibiotic activity

Por Ramadoss, Nitya S., Alumasa, John N., Cheng, Lin, Wang, Yu, Li, Sharon, Chambers, Benjamin S., Chang, Hoon, Chatterjee, Arnab K., Brinker, Achim, Engels, Ingo H., Keiler, Kenneth C.
Publicado em 2013

Small molecule-mediated inhibition of myofibroblast transdifferentiation for the treatment of fibrosis

Por Bollong, Michael J., Yang, Baiyuan, Vergani, Naja, Beyer, Brittney A., Chin, Emily N., Zambaldo, Claudio, Wang, Danling, Chatterjee, Arnab K., Lairson, Luke L., Schultz, Peter G.
Publicado no Proc Natl Acad Sci U S A (2017)

Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis

Por Harbut, Michael B., Vilchèze, Catherine, Luo, Xiaozhou, Hensler, Mary E., Guo, Hui, Yang, Baiyuan, Chatterjee, Arnab K., Nizet, Victor, Jacobs, William R., Schultz, Peter G., Wang, Feng
Publicado no Proc Natl Acad Sci U S A (2015)

Decarboxylative borylation

Por Li, Chao, Wang, Jie, Barton, Lisa M., Yu, Shan, Tian, Maoqun, Peters, David S., Kumar, Manoj, Yu, Antony W., Johnson, Kristen A., Chatterjee, Arnab K., Yan, Ming, Baran, Phil S.
Publicado no Science (2017)

Targeted Delivery of LXR Agonist Using a Site-Specific Antibody-Drug Conjugate

Por Lim, Reyna K.V., Yu, Shan, Cheng, Bo, Li, Sijia, Kim, Nam-Jung, Cao, Yu, Chi, Victor, Kim, Ji Young, Chatterjee, Arnab K., Tremblay, Matthew S., Schultz, Peter G., Kazane, Stephanie A.
Publicado no Bioconjug Chem (2015)

Mutations in the P-Type Cation-Transporter ATPase 4, PfATP4, Mediate Resistance to Both Aminopyrazole and Spiroindolone Antimalarials

Por Flannery, Erika L., McNamara, Case W., Kim, Sang Wan, Kato, Tomoyo Sakata, Li, Fengwu, Teng, Christine H., Gagaring, Kerstin, Manary, Micah J., Barboa, Rachel, Meister, Stephan, Kuhen, Kelli, Vinetz, Joseph M., Chatterjee, Arnab K., Winzeler, Elizabeth A.
Publicado no ACS Chem Biol (2014)

Cell-based optimization of novel benzamides as potential antimalarial leads

Por Wu, Tao, Nagle, Advait, Sakata, Tomoyo, Henson, Kerstin, Borboa, Rachel, Chen, Zhong, Kuhen, Kelli, Plouffe, David, Winzeler, Elizabeth, Adrian, Francisco, Tuntland, Tove, Chang, Jonathan, Simerson, Susan, Howard, Steven, Ek, Jared, Isbell, John, Deng, Xianming, Gray, Nathanael S., Tully, David C., Chatterjee, Arnab K.
Publicado em 2009

Rational design of a Kv1.3 channel-blocking antibody as a selective immunosuppressant

Por Wang, Rongsheng E., Wang, Ying, Zhang, Yuhan, Gabrelow, Chase, Zhang, Yong, Chi, Victor, Fu, Qiangwei, Luo, Xiaozhou, Wang, Danling, Joseph, Sean, Johnson, Kristen, Chatterjee, Arnab K., Wright, Timothy M., Nguyen-Tran, Vân T. B., Teijaro, John, Theofilopoulos, Argyrios N., Schultz, Peter G., Wang, Feng
Publicado no Proc Natl Acad Sci U S A (2016)

Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease

Por Khare, Shilpi, Roach, Steven L., Barnes, S. Whitney, Hoepfner, Dominic, Walker, John R., Chatterjee, Arnab K., Neitz, R. Jeffrey, Arkin, Michelle R., McNamara, Case W., Ballard, Jaime, Lai, Yin, Fu, Yue, Molteni, Valentina, Yeh, Vince, McKerrow, James H., Glynne, Richard J., Supek, Frantisek
Publicado no PLoS Pathog (2015)

Substituted 2-Phenyl-Imidazopyridines: A New Class of Drug Leads for Human African Trypanosomiasis

Por Tatipaka, Hari Babu, Gillespie, J. Robert, Chatterjee, Arnab K., Norcross, Neil R., Hulverson, Matthew A., Ranade, Ranae M., Nagendar, Pendem, Creason, Sharon A., McQueen, Joshua, Duster, Nicole A., Nagle, Advait, Supek, Frantisek, Molteni, Valentina, Wenzler, Tanja, Brun, Reto, Glynne, Richard, Buckner, Frederick S., Gelb, Michael H.
Publicado em 2014

Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes

Por Liu, Renhe, Lyu, Xiaoxuan, Batt, Sarah M, Hsu, Mei‐Hui, Harbut, Michael B, Vilchèze, Catherine, Cheng, Bo, Ajayi, Kehinde, Yang, Baiyuan, Yang, Yun, Guo, Hui, Lin, Changyou, Gan, Fei, Wang, Chen, Franzblau, Scott G., Jacobs, William R., Besra, Gurdyal S., Johnson, Eric F., Petrassi, Mike, Chatterjee, Arnab K., Fütterer, Klaus, Wang, Feng
Publicado no Angew Chem Int Ed Engl (2017)

Identification of inhibitors for putative malaria drug targets amongst novel antimalarial compounds

Por Crowther, Gregory J., Napuli, Alberto J., Gilligan, James H., Gagaring, Kerstin, Borboa, Rachel, Francek, Carolyn, Chen, Zhong, Dagostino, Eleanor F., Stockmyer, Justin B., Wang, Yu, Rodenbough, Philip P., Castaneda, Lisa J., Leibly, David J., Bhandari, Janhavi, Gelb, Michael H., Brinker, Achim, Engels, Ingo, Taylor, Jennifer, Chatterjee, Arnab K., Fantauzzi, Pascal, Glynne, Richard J., Van Voorhis, Wesley C., Kuhen, Kelli L.
Publicado em 2010

Identification of a small molecule with activity against drug-resistant and persistent tuberculosis

Por Wang, Feng, Sambandan, Dhinakaran, Halder, Rajkumar, Wang, Jianing, Batt, Sarah M., Weinrick, Brian, Ahmad, Insha, Yang, Pengyu, Zhang, Yong, Kim, John, Hassani, Morad, Huszar, Stanislav, Trefzer, Claudia, Ma, Zhenkun, Kaneko, Takushi, Mdluli, Khisi E., Franzblau, Scott, Chatterjee, Arnab K., Johnsson, Kai, Mikusova, Katarina, Besra, Gurdyal S., Fütterer, Klaus, Robbins, Scott H., Barnes, S. Whitney, Walker, John R., Jacobs, William R., Schultz, Peter G.
Publicado em 2013

Imidazolopiperazines: Lead Optimization of the Second-Generation Antimalarial Agents

Por Nagle, Advait, Wu, Tao, Kuhen, Kelli, Gagaring, Kerstin, Borboa, Rachel, Francek, Caroline, Chen, Zhong, Plouffe, David, Lin, Xuena, Caldwell, Christopher, Ek, Jared, Skolnik, Suzanne, Liu, Fenghua, Wang, Jianling, Chang, Jonathan, Li, Chun, Liu, Bo, Hollenbeck, Thomas, Tuntland, Tove, Isbell, John, Chuan, Tiffany, Alper, Philip B., Fischli, Christoph, Brun, Reto, Lakshminarayana, Suresh B., Rottmann, Matthias, Diagana, Thierry T., Winzeler, Elizabeth A., Glynne, Richard, Tully, David C., Chatterjee, Arnab K.
Publicado em 2012

KAI407, a Potent Non-8-Aminoquinoline Compound That Kills Plasmodium cynomolgi Early Dormant Liver Stage Parasites In Vitro

Por Zeeman, Anne-Marie, van Amsterdam, Sandra M., McNamara, Case W., Voorberg-van der Wel, Annemarie, Klooster, Els J., van den Berg, Alexander, Remarque, Edmond J., Plouffe, David M., van Gemert, Geert-Jan, Luty, Adrian, Sauerwein, Robert, Gagaring, Kerstin, Borboa, Rachel, Chen, Zhong, Kuhen, Kelli, Glynne, Richard J., Chatterjee, Arnab K., Nagle, Advait, Roland, Jason, Winzeler, Elizabeth A., Leroy, Didier, Campo, Brice, Diagana, Thierry T., Yeung, Bryan K. S., Thomas, Alan W., Kocken, Clemens H. M.
Publicado em 2014