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Targeted Delivery of LXR Agonist Using a Site-Specific Antibody-Drug Conjugate

Liver X receptor (LXR) agonists have been explored as potential treatments for atherosclerosis and other diseases based on their ability to induce reverse cholesterol transport and suppress inflammation. However, this therapeutic potential has been hindered by on-target adverse effects in the liver...

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Detalhes bibliográficos
Publicado no:Bioconjug Chem
Main Authors: Lim, Reyna K.V., Yu, Shan, Cheng, Bo, Li, Sijia, Kim, Nam-Jung, Cao, Yu, Chi, Victor, Kim, Ji Young, Chatterjee, Arnab K., Tremblay, Matthew S., Schultz, Peter G., Kazane, Stephanie A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4651790/
https://ncbi.nlm.nih.gov/pubmed/25945727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.5b00203
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