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Site-specific Antibody-polymer Conjugates for siRNA Delivery

We describe here the development of site-specific antibody-polymer conjugates (APCs) for the selective delivery of small interference RNAs (siRNAs) to target cells. APCs were synthesized in good yields by conjugating an aminooxy-derivatized cationic block copolymer to an anti-HER2 Fab or full length...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Lu, Hua, Wang, Danling, Kazane, Stephanie, Javahishvili, Tsotne, Tian, Feng, Song, Frank, Sellers, Aaron, Barnett, Barney, Schultz, Peter G.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2013
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3955097/
https://ncbi.nlm.nih.gov/pubmed/23924037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja4059525
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