A CXCR4-Targeted Site-Specific Antibody-Drug Conjugate()

Herein, we describe the synthesis of a chemically defined CXCR4-auristatin antibody-drug conjugate (ADC) that selectively eliminates CXCR4(+) over-expressing tumors. The unnatural amino acid p-acetylphenylalanine (pAcF) was site-specifically incorporated into an anti-CXCR4 IgG and conjugated to an a...

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Publicado en:Angew Chem Int Ed Engl
Main Authors: Kularatne, Sumith A., Deshmukh, Vishal, Ma, Jennifer, Tardif, Virginie, Lim, Reyna K. V., Pugh, Holly M., Sun, Ying, Manibusan, Anthony, Sellers, Aaron J., Barnett, Richard S., Srinagesh, Shailaja, Forsyth, Jane S., Hassenpflug, Wolf, Tian, Feng, Javahishvili, Tsotne, Felding-Habermann, Brunhilde, Lawson, Brian R., Kazane, Stephanie A., Schultz, Peter G.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4331128/
https://ncbi.nlm.nih.gov/pubmed/25213874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201408103
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