A CXCR4-Targeted Site-Specific Antibody-Drug Conjugate()

Herein, we describe the synthesis of a chemically defined CXCR4-auristatin antibody-drug conjugate (ADC) that selectively eliminates CXCR4(+) over-expressing tumors. The unnatural amino acid p-acetylphenylalanine (pAcF) was site-specifically incorporated into an anti-CXCR4 IgG and conjugated to an a...

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Bibliographic Details
Published in:Angew Chem Int Ed Engl
Main Authors: Kularatne, Sumith A., Deshmukh, Vishal, Ma, Jennifer, Tardif, Virginie, Lim, Reyna K. V., Pugh, Holly M., Sun, Ying, Manibusan, Anthony, Sellers, Aaron J., Barnett, Richard S., Srinagesh, Shailaja, Forsyth, Jane S., Hassenpflug, Wolf, Tian, Feng, Javahishvili, Tsotne, Felding-Habermann, Brunhilde, Lawson, Brian R., Kazane, Stephanie A., Schultz, Peter G.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4331128/
https://ncbi.nlm.nih.gov/pubmed/25213874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201408103
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