A CXCR4-Targeted Site-Specific Antibody-Drug Conjugate()

Herein, we describe the synthesis of a chemically defined CXCR4-auristatin antibody-drug conjugate (ADC) that selectively eliminates CXCR4(+) over-expressing tumors. The unnatural amino acid p-acetylphenylalanine (pAcF) was site-specifically incorporated into an anti-CXCR4 IgG and conjugated to an a...

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Detaylı Bibliyografya
Yayımlandı:Angew Chem Int Ed Engl
Asıl Yazarlar: Kularatne, Sumith A., Deshmukh, Vishal, Ma, Jennifer, Tardif, Virginie, Lim, Reyna K. V., Pugh, Holly M., Sun, Ying, Manibusan, Anthony, Sellers, Aaron J., Barnett, Richard S., Srinagesh, Shailaja, Forsyth, Jane S., Hassenpflug, Wolf, Tian, Feng, Javahishvili, Tsotne, Felding-Habermann, Brunhilde, Lawson, Brian R., Kazane, Stephanie A., Schultz, Peter G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4331128/
https://ncbi.nlm.nih.gov/pubmed/25213874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201408103
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