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A CXCR4-Targeted Site-Specific Antibody-Drug Conjugate()
Herein, we describe the synthesis of a chemically defined CXCR4-auristatin antibody-drug conjugate (ADC) that selectively eliminates CXCR4(+) over-expressing tumors. The unnatural amino acid p-acetylphenylalanine (pAcF) was site-specifically incorporated into an anti-CXCR4 IgG and conjugated to an a...
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| Published in: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4331128/ https://ncbi.nlm.nih.gov/pubmed/25213874 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201408103 |
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