Folate Receptor–Targeted T cells for Cancer Immunotherapy

Herein, we describe the synthesis of a chemically defined anti-CD3 Fab-folate conjugate that targets cytotoxic T cells to folate receptor positive (FR(+)) tumors. The unnatural amino acid pacetylphenylalanine (pAcPhe) was site-specifically incorporated into an anti-CD3 Fab and conjugated to folate v...

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Bibliografske podrobnosti
Main Authors: Kularatne, Sumith A., Deshmukh, Vishal, Gymnopoulos, Marco, Biroc, Sandra L., Xia, Jinming, Srinagesh, Shaila, Sun, Ying, Zou, Ning, Shimazu, Mark, Pinkstaff, Jason, Ensari, Semsi, Knudsen, Nick, Manibusan, Anthony, Axup, Jun, Kim, Chanhyuk, Smider, Vaughn, Javahishvili, Tsotne, Schultz, Peter G.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4012751/
https://ncbi.nlm.nih.gov/pubmed/24573789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201306866
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