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Folate Receptor–Targeted T cells for Cancer Immunotherapy
Herein, we describe the synthesis of a chemically defined anti-CD3 Fab-folate conjugate that targets cytotoxic T cells to folate receptor positive (FR(+)) tumors. The unnatural amino acid pacetylphenylalanine (pAcPhe) was site-specifically incorporated into an anti-CD3 Fab and conjugated to folate v...
Gorde:
| Egile Nagusiak: | , , , , , , , , , , , , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2013
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4012751/ https://ncbi.nlm.nih.gov/pubmed/24573789 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201306866 |
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