Folate Receptor–Targeted T cells for Cancer Immunotherapy

Herein, we describe the synthesis of a chemically defined anti-CD3 Fab-folate conjugate that targets cytotoxic T cells to folate receptor positive (FR(+)) tumors. The unnatural amino acid pacetylphenylalanine (pAcPhe) was site-specifically incorporated into an anti-CD3 Fab and conjugated to folate v...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kularatne, Sumith A., Deshmukh, Vishal, Gymnopoulos, Marco, Biroc, Sandra L., Xia, Jinming, Srinagesh, Shaila, Sun, Ying, Zou, Ning, Shimazu, Mark, Pinkstaff, Jason, Ensari, Semsi, Knudsen, Nick, Manibusan, Anthony, Axup, Jun, Kim, Chanhyuk, Smider, Vaughn, Javahishvili, Tsotne, Schultz, Peter G.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4012751/
https://ncbi.nlm.nih.gov/pubmed/24573789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201306866
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