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Selective Formation of Covalent Protein Heterodimers with an Unnatural Amino Acid
We report a new strategy for the generation of heterodimeric protein conjugates using an unnatural amino acid with orthogonal reactivity. This paper addresses the challenges of site-specificity and homogeneity with respect to the synthesis of bivalent proteins and antibody-drug conjugates. There are...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3694407/ https://ncbi.nlm.nih.gov/pubmed/21439474 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2011.01.006 |
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