Selective Formation of Covalent Protein Heterodimers with an Unnatural Amino Acid

We report a new strategy for the generation of heterodimeric protein conjugates using an unnatural amino acid with orthogonal reactivity. This paper addresses the challenges of site-specificity and homogeneity with respect to the synthesis of bivalent proteins and antibody-drug conjugates. There are...

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Main Authors: Hutchins, Benjamin M., Kazane, Stephanie A., Staflin, Karin, Forsyth, Jane S., Felding-Habermann, Brunhilde, Smider, Vaughn V., Schultz, Peter G.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694407/
https://ncbi.nlm.nih.gov/pubmed/21439474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2011.01.006
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