Synthesis of site-specific antibody-drug conjugates using unnatural amino acids

Antibody-drug conjugates (ADCs) allow selective targeting of cytotoxic drugs to cancer cells presenting tumor-associated surface markers, thereby minimizing systemic toxicity. Traditionally, the drug is conjugated nonselectively to cysteine or lysine residues in the antibody. However, these strategi...

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Αποθηκεύτηκε σε:
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Κύριοι συγγραφείς: Axup, Jun Y., Bajjuri, Krishna M., Ritland, Melissa, Hutchins, Benjamin M., Kim, Chan Hyuk, Kazane, Stephanie A., Halder, Rajkumar, Forsyth, Jane S., Santidrian, Antonio F., Stafin, Karin, Lu, Yingchun, Tran, Hon, Seller, Aaron J., Biroc, Sandra L., Szydlik, Aga, Pinkstaff, Jason K., Tian, Feng, Sinha, Subhash C., Felding-Habermann, Brunhilde, Smider, Vaughn V., Schultz, Peter G.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: National Academy of Sciences 2012
Θέματα:
Biological Sciences
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479532/
https://ncbi.nlm.nih.gov/pubmed/22988081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211023109
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