Synthesis of site-specific antibody-drug conjugates using unnatural amino acids

Antibody-drug conjugates (ADCs) allow selective targeting of cytotoxic drugs to cancer cells presenting tumor-associated surface markers, thereby minimizing systemic toxicity. Traditionally, the drug is conjugated nonselectively to cysteine or lysine residues in the antibody. However, these strategi...

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Detalhes bibliográficos
Main Authors: Axup, Jun Y., Bajjuri, Krishna M., Ritland, Melissa, Hutchins, Benjamin M., Kim, Chan Hyuk, Kazane, Stephanie A., Halder, Rajkumar, Forsyth, Jane S., Santidrian, Antonio F., Stafin, Karin, Lu, Yingchun, Tran, Hon, Seller, Aaron J., Biroc, Sandra L., Szydlik, Aga, Pinkstaff, Jason K., Tian, Feng, Sinha, Subhash C., Felding-Habermann, Brunhilde, Smider, Vaughn V., Schultz, Peter G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479532/
https://ncbi.nlm.nih.gov/pubmed/22988081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211023109
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