Synthesis of site-specific antibody-drug conjugates using unnatural amino acids

Antibody-drug conjugates (ADCs) allow selective targeting of cytotoxic drugs to cancer cells presenting tumor-associated surface markers, thereby minimizing systemic toxicity. Traditionally, the drug is conjugated nonselectively to cysteine or lysine residues in the antibody. However, these strategi...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Axup, Jun Y., Bajjuri, Krishna M., Ritland, Melissa, Hutchins, Benjamin M., Kim, Chan Hyuk, Kazane, Stephanie A., Halder, Rajkumar, Forsyth, Jane S., Santidrian, Antonio F., Stafin, Karin, Lu, Yingchun, Tran, Hon, Seller, Aaron J., Biroc, Sandra L., Szydlik, Aga, Pinkstaff, Jason K., Tian, Feng, Sinha, Subhash C., Felding-Habermann, Brunhilde, Smider, Vaughn V., Schultz, Peter G.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2012
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479532/
https://ncbi.nlm.nih.gov/pubmed/22988081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211023109
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares