Ribosome-Inactivating Protein–Small Molecule Conjugates can Selectively Inhibit Target-Specific Tumor Cell Growth

Cell-targeting conjugates of Saporin 6, a ribosome inactivating protein (RIP), were prepared using the Saporin Ala 157 Cys mutant, a small molecule inhibitor of integrin αvβ3, and a potent cytotoxin, auristatin F (AF). The conjugates selectively and potently inhibited proliferation of tumor cells ex...

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Publicat a:Chem Commun (Camb)
Autors principals: Roy, Saumya, Axup, Jun Y., Forsyth, Jane S., Goswami, Rajib K., Hutchins, Benjamin M., Bajuri, Krishna M., Kazane, Stephanie A., Smider, Vaughn V., Felding, Brunhilde H., Sinha, Subhash C.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6594371/
https://ncbi.nlm.nih.gov/pubmed/28357420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7cc00745k
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