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Ribosome-Inactivating Protein–Small Molecule Conjugates can Selectively Inhibit Target-Specific Tumor Cell Growth
Cell-targeting conjugates of Saporin 6, a ribosome inactivating protein (RIP), were prepared using the Saporin Ala 157 Cys mutant, a small molecule inhibitor of integrin αvβ3, and a potent cytotoxin, auristatin F (AF). The conjugates selectively and potently inhibited proliferation of tumor cells ex...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Chem Commun (Camb) |
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| Κύριοι συγγραφείς: | , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2017
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6594371/ https://ncbi.nlm.nih.gov/pubmed/28357420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7cc00745k |
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